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Featuring talks by

Prof. K. Barry SHARPLESS

2022&2001 Nobel Laureates in Chemistry; W.M. Keck Professor of Chemistry, Scripps Research

Prof. DING Kuiling

Academician, Chinese Academy of Sciences; President, Shanghai Jiao Tong University

Prof. Michael LEVITT

2013 Nobel Laureate in Chemistry Vice-Chair, World Laureates Association

About the Remarks

K. Barry SHARPLESS
2022&2001 Nobel Laureates in Chemistry;
W.M. Keck Professor of Chemistry, Scripps Research

Brief bio: Among a newer generation of scientists representing the entire chemical spectrum, from chemical engineering and materials to chemical biology, K. Barry Sharpless is known for click chemistry, a term he coined in 1998. Inspired by the complexity nature achieves from a handful of building blocks, Sharpless started actively looking in the mid-90s for a way to discover new chemical connectivity and reactivity. Click chemistry did not gain momentum until his group's discovery of CuAAC (the copper-catalyzed azide-alkyne cycloaddition), a near-perfect reaction (2002). Recently the Sharpless group discovered SuFEx, also near-perfect for click chemistry. In concert with the thiol-ene reaction, these three make click chemistry a far-reaching method for drug discovery, chemical biology, and materials science.

In 1963, K. Barry Sharpless graduated from Dartmouth College, where he was introduced, most fortuitously, to the wonders of chemistry by T. A. Spencer. Following graduate research with E. E. van Tamelen at Stanford University, Sharpless completed postdoctoral studies with J. P. Collman, also at Stanford, and at Harvard University with Konrad Bloch.

Sharpless set up his own laboratory in 1970 at the Massachusetts Institute of Technology. Except for several years in the 1970s when he was a member of Stanford’s chemistry faculty, Sharpless remained at MIT until moving to the Scripps Research Institute (TSRI) in 1990. At TSRI he is a W. M. Keck Professor of Chemistry and a member of the Skaggs Institute for Chemical Biology

DING Kuiling
Academician, Chinese Academy of Sciences;
President, Shanghai Jiao Tong University

Brief bio: Ding Kuiling is a deputy to the 14th National People's Congress (NPC). He concurrently served as the Executive Director of the Chinese Chemical Society (CCS), Vice President of the China Industry-University-Research Institute Collaboration Association (CIUR), and Vice Chairman of the Standing Committee of the Shanghai Association for Science and Technology (SAST). He previously held several positions at the Shanghai Institute of Organic Chemistry (SIOC) in the Chinese Academy of Sciences, including Director, Deputy Director, Chairman of the Trade Union, Deputy Secretary of the Party Committee, and Secretary of the Discipline Inspection Commission. Then he served as Vice President of ShanghaiTech University, Dean of ShanghaiTech Colleges, and member of the Party Standing Committee, and Executive Vice President of Shanghai Jiao Tong University. He is mainly engaged in the research of asymmetric reactions and green organometallic chemistry. He has proposed and successfully applied new concepts and methods of chiral catalyst design, and developed new chiral ligands and catalysts with characteristic frameworks.

Michael LEVITT
2013 Nobel Laureate in Chemistry Vice-Chair, World Laureates Association

Brief bio: Michael Levitt is a biophysicist and professor of structural biology at Stanford University. He received his Ph.D from Cambridge where he developed computer programs for studying molecular conformations. Levitt conducted pioneering research on simulating DNA and proteins and predicting macromolecular structures. He later developed simplified approaches for analyzing protein folding and scoring sequence-structure comparisons. Levitt has mentored many successful scientists. In 2013, Levitt was awarded the Nobel Prize in Chemistry along with Martin Karplus and Arieh Warshel for developing multiscale models of complex chemical systems. He has received many honors including election as Fellow of the Royal Society and Member of the National Academy of Sciences. Levitt currently serves as editor of the Annual Review of Biomedical Data Science.