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Thank you for signing up for the inaugural WLA Research Conference. Please read the following notice for a pleasant experience.
All participants need to register for the conference online at our official website and pay the registration fee and/or the banquet fee.
The registration fee is $200.00 per person and $50.00 per person for the banquet fee.
You can purchase up to 5 extra tickets with each having their contact information.
A full refund is available before July 20, 2020 (Beijing Time). After this date, refunds will not be provided.
You are welcome to bring your research poster and display at the Poster Session of WRC.
You are encouraged to read the Poster Presenter Guidelines to help you better prepare for the session.
The Best Poster Prize will be awarded at the closing of the meeting on July 28.
Please bring your ID document to pick up your badge and meeting materials at the Registration table on July 26, 2023, 10 am - 2 pm.
Please wear your badge during the meeting. Contact WLA Labs staff immediately if lost, and temporary one will be provided.
Meeting materials include a program book, a note pad, a pen and a WRC bag.
English is the working language of the meeting. No interpretation service is provided.
The venue of the meeting is La Salle Versailles, Shanghai Science Hall. You can take metro line 13, at Middle Huaihai Road, or drive here.
The parking lot is at right side of the building.
We recommend the following 2 premium hotels nearest to the meeting that can offer you a delightful experience:
a) Okura Garden Hotel Shanghai, five stars: No. 58, Maoming South Road
b) Intercontinental, five stars: No. 118, Ruijin 2nd Road
General inquiry, please contact info@wlalabs.com.cn.
In case of emergency, please contact 021-655 7670
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Last updated: May 18, 2023
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Last updated: May 18, 2023
You've already registered for this Conference. Please find more details in My Event .Thank you!
You've already registered for this Conference. Please find more details in My Event. Thank you!
Featuring talks by
Prof. TANG Benzhong
Academician, Chinese Academy of Sciences; Professor, Dean, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen
Topic: Wonder Chemistry on/in/of Water
TANG Benzhong
Academician, Chinese Academy of Sciences;
Professor, Dean, School of Science and Engineering,
The Chinese University of Hong Kong, Shenzhen
Brief bio: Tang Ben Zhong received Ph.D. degree from Kyoto University and conducted postdoctoral research at the University of Toronto. He is now a Presidential Chair Professor at the Chinese University of Hong Kong, Shenzhen. He was elected to the Chinese Academy of Sciences in 2009. He is currently serving as Editor-in-Chief of Aggregate published by Wiley. His research interests include materials science and biomedical theranostics. He has received many awards, such as the National Natural Science Award (2017), the Nano Today Award (2021) and Biomaterials Global Impact Award (2023). His publications have been cited over 176,000 times, with an h-index of 185. He has been listed as a Highly Cited Researcher since 2014 in both areas of Chemistry and Materials Science.
Topic: Wonder Chemistry on/in/of Water
Abstract: Water, as an omnipresent substance, plays a vital role in many aspects of our lives, ranging from sustaining living organisms to driving technological advancements. The exploration of organic reactions in water or utilization of natural water as a reactant has attracted significant attention due to their advantages, including unique reaction performance, environmental friendliness, and reduction of harmful wastes. In this talk, the recent research progress on new polymerization approaches involving water and monomers containing triple-bond functionalities such as diyne, isocyanides, and bromoalkynes will be introduced. Furthermore, several click polymerization methods in aqueous media will be discussed. The "on water" effect facilitates polymerization in aqueous media more effectively than in conventional organic solvents. Additionally, many luminogens possessing aggregation-induced emission and natural characteristics (BioAIEgens) are developed in a water system. The synthesized polymers, small molecules, and BioAIEgens show unique characteristics and functions such as aggregation-induced emission (AIE), clusteroluminescence, bio-imaging ability, and stimuli-responsive response. With the aim of exploring the chemistry on/in/of water, we hope this talk could provide insight into polymerizations of water and triple-bond based monomers, as well as the preparation of functional materials under mild reaction conditions or through the utilization of water.
Reversible RNA methylation in gene expression regulation
Prof. Chuan He
Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered two RNA demethylases, FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that reversible RNA modification could impact biological regulation analogous to the well-known reversible DNA and histone chemical modifications. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target mRNA. Functional studies reveal m6A methylation as a critical mechanism to group transcripts for coordinated metabolism, translation, and decay, allowing timely and coordinated protein synthesis and transcriptome switching during cell differentiation and development. I will present our recent work elucidating transcriptional regulation through m6A methylation and demethylation, and impacts of this regulation on mammalian early development as well as plant growth.
Lnc-ing RNA processing and function
Prof. Ling-Ling Chen
New Cornerstone Science Laboratory, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS)
Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs. By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several RNA species with unexpected formats. These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by distinct mechanisms, including capping by small nucleolar RNA (snoRNA)–protein (snoRNP) complexes at their ends (sno-lncRNAs) or forming circular structures. We have shown that sno-lncRNAs and circular RNAs are involved in key gene regulation events and are implicated in Pradier-Will syndrome and autoimmune diseases. In this talk, I will discuss the mechanisms of their formation and function, as well as how we study one sno-lncRNA (SLERT) that has enabled us to uncover previously unknown organization and regulation in the human nucleolus.
Translating spatial cell atlas to tissue function
Prof. Xiao Wang
Department of Chemistry, Broad Institute, MIT
Spatially charting molecular cell types at single-cell resolution across the entire three-dimensional (3D) volume of the brain is critical to illustrating the molecular basis of the tissue anatomy and functions. Recent development of spatial transcriptomic methods has enabled scalable profiling of transcriptome-defined spatial cell atlas. Yet, there is still a big gap between spatial cell atlas and tissue function. In this presentation, I will introduce a few experimental and computational advances in our lab that further enable multi-modality deep profiling of cell types and states in situ, bridging single-cell molecular profiles with single-cell functional status in intact biological tissues and accelerating gene-to-function discoveries in development and diseases.
Special Remarks
Moderator: Michael LEVITT
Session 1: New Chemistry And Tools
Moderator: DONG Jiajia
Session 2: Click Chemistry Tools For Studying Glycosylation
Moderator: WU Peng
Session 3: New Tools for The Investigation and Control of Protein Functions
Moderator: WU Peng
Session 4: New Tools for Imaging And Probing Nucleic Acids, Protein and Receptor Signaling
Moderator: SHUI Wenqing