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Thank you for signing up for the inaugural WLA Research Conference. Please read the following notice for a pleasant experience.
All participants need to register for the conference online at our official website and pay the registration fee and/or the banquet fee.
The registration fee is $200.00 per person and $50.00 per person for the banquet fee.
You can purchase up to 5 extra tickets with each having their contact information.
A full refund is available before July 20, 2020 (Beijing Time). After this date, refunds will not be provided.
You are welcome to bring your research poster and display at the Poster Session of WRC.
You are encouraged to read the Poster Presenter Guidelines to help you better prepare for the session.
The Best Poster Prize will be awarded at the closing of the meeting on July 28.
Please bring your ID document to pick up your badge and meeting materials at the Registration table on July 26, 2023, 10 am - 2 pm.
Please wear your badge during the meeting. Contact WLA Labs staff immediately if lost, and temporary one will be provided.
Meeting materials include a program book, a note pad, a pen and a WRC bag.
English is the working language of the meeting. No interpretation service is provided.
The venue of the meeting is La Salle Versailles, Shanghai Science Hall. You can take metro line 13, at Middle Huaihai Road, or drive here.
The parking lot is at right side of the building.
We recommend the following 2 premium hotels nearest to the meeting that can offer you a delightful experience:
a) Okura Garden Hotel Shanghai, five stars: No. 58, Maoming South Road
b) Intercontinental, five stars: No. 118, Ruijin 2nd Road
General inquiry, please contact info@wlalabs.com.cn.
In case of emergency, please contact 021-655 7670
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Last updated: May 18, 2023
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Last updated: May 18, 2023
You've already registered for this Conference. Please find more details in My Event .Thank you!
You've already registered for this Conference. Please find more details in My Event. Thank you!
Featuring talks by
Prof. WU Mingxuan
Assistant professor, Westlake University
Topic: Development of New Sortase-Mediated Methods for Investigation of Histone Modifications
Prof. Katsunori TANAKA
Professor, School of Materials and Chemical Technology, Tokyo Institute of Technology; Chief Scientist, Biofunctional Synthetic Chemistry Laboratory, RIKEN
Topic: Therapeutic in Vivo Synthetic Chemistry
Prof. GAO Bing
Professor, School of Chemistry and Chemical Engineering, Hunan University
Topic: S(VI)-C Ligation Through Radical and Enantioselective Reactions
Moderated by
Prof. DONG Jiajia
Professor, Institute of Translational Medicine, Shanghai Jiao Tong University; Distinguished Professor, WLA Labs
Topic: The FSO2N3, an Unexpected Journey
New Chemistry And Tools
WU Mingxuan
Assistant Professor, Department of Chemistry, Westlake University
Brief bio: Mingxuan obtained his B.S. and M.S. degrees from the School of Life Science and Biotechnology at Shanghai Jiao Tong University. He received his Ph.D. degree in chemistry from Princeton University under the supervision of Dorothea Fiedler. Next, he joined the Phil Cole lab for postdoc training at Johns Hopkins University School of Medicine and later moved to Harvard Medical School Brigham and Women's Hospital. He was appointed to the Department of Chemistry at Westlake University in 2019 as an Assistant Professor.
Topic: Development of New Sortase-Mediated Methods for Investigation of Histone Modifications
Abstract: Posttranslational modifications of histone H3 and H4 play significant roles in the regulation of epigenetic status. Chemical methods that precisely manipulate histone modifications are desired for basic research and therapeutic applications. Here we report two new sortase-mediated methods toward the goal. First, we developed a semisynthesis method of histone H4 via sortase mediated ligation. It allowed us to identify novel H4K20me3 readers by photo-crosslinking from multifunctional nucleosome probes. Second, we report a method to edit the N-tail of histone H3 via sortase mediated metathesis. Specific PTM patterns could be incorporated into histone H3 on nucleosomes in vitro and in cellulose. We expect the new tools could accelerate the understanding of histone modifications and have the potential for epigenome editing.
Katsunori TANAKA
Professor, School of Materials and Chemical Technology, Tokyo Institute of Technology;
Chief Scientist, Biofunctional Synthetic Chemistry Laboratory, RIKEN
Brief bio: Katsunori Tanaka received his Ph.D. (2002) from Kwansei Gakuin University, Japan, under the direction of Prof. Shigeo Katsumura. After a post-doc with Prof. Koji Nakanishi at Columbia University (2002-2005), he joined Professor Koichi FUKASE's group at Osaka University as an Assistant Professor. He moved to RIKEN as an Associate Chief Scientist in 2012. He was then appointed as a Chief Scientist, at RIKEN Cluster for Pioneering Research in 2017 and as a Professor in the Department of Chemical Science and Engineering, Tokyo Institute of Technology (2019), under the cross-appointment system. He received several awards including Best Electric Guitar Player under 20 in Japan (1994), Young Scientist's Research Award in the 2nd Natural Product Chemistry Symposium (2002), Young Scientist's Research Award in the 46th Chemistry of National Products (2004), Young Investigator's Award in the 46th Japanese Society of Carbohydrate Research (2010), Incentive Award in The Society of Synthetic Organic Chemistry, Japan (2011), American Chemical Society (ACS) Division of Carbohydrate Chemistry, Horace S. Isbell Award (2015), JSPS Prize (2018), The Chemical Society of Japan (CSJ) Award for Creative Work (2019), Astellas Award for the Best Biomedical Research (2022), and Kaneka Life Science Industrial Award in The Society of Synthetic Organic Chemistry, Japan (2023).
Topic: Therapeutic in Vivo Synthetic Chemistry
Abstract: The long-term goal of our research is to develop the working tools and methodologies that will form the foundation of "Therapeutic in Vivo Synthetic Chemistry". The main benefit of this approach is that synthetic transformations can be directly performed at target regions within the body to generate molecules that elicit localized biological effects. This method should largely circumvent off-target binding and instability issues associated with current drug administration techniques. In these years, we have engaged this topic through two different approaches. The first is through the usage of glycosylated artificial metalloenzymes, where the primary aim is to exploit the chemoselectivity of embedded, non-natural transition metal catalysts for the synthesis/release of bioactive molecules. The second approach is rather centered on discovering chemical probes with novel and selective reactivity to biological metabolites naturally overexpressed in cancer cells. Once developed, the objective is then to adapt them for synthesizing diagnostic probes or anticancer drugs. Overall, we have been dedicated to developing the initial working proofs-of-concept and then to spearheading investigations towards their utility for therapeutic and diagnostic applications.
GAO Bing
Professor, School of Chemistry and Chemical Engineering, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, Hunan University
Experience and Education:
GAO Bing earned his Ph.D. in 2014 from the Shanghai Institute of Organic Chemistry under the guidance of Professor HU Jinbo. His doctoral research primarily focused on the development of novel reagents and methodologies for integrating fluorine-containing modules into functional molecules. In early 2015, he commenced his post-doctoral fellowship at Scripps Research in San Diego, where he collaborated with Professor Karl Barry Sharpless in the field of sulfur fluoride exchange reactions. In 2019, he joined Hunan University as a joint professor in the Chemistry Department and the State Key Laboratory.
Topic: S(VI)-C Ligation Through Radical and Enantioselective Reactions
Abstract: Sulfur(VI) Fluoride Exchange (SuFEx) is the latest generation of Click reactions developed by Sharpless in the year of 2014. It highlights the unique properties of hypervalent sulfur(VI) fluoride compounds in connecting chemical fragments through fluoride exchange reactions. Linkages are created under stringent conditions through the nucleophilic substitution of fluoride by phenols, alcohols, and amines. In this presentation, GAO and coworkers are going to report a few novel ligation processes that allow for efficient connection of carbon nucleophiles.
DONG Jiajia
Professor, Institute of Translational Medicine, Shanghai Jiao Tong University; Distinguished Professor, WLA Labs
Brief bio: Dong Jiajia was born in China and received his B.A. from Xiamen University in 2000. Prof. Jiang Biao supervised his 2006 Ph.D. in organic chemistry from the Shanghai Institute of Organic Chemistry (SIOC). He was a senior scientific researcher at Egret Pharma, Shanghai, before becoming a postdoctoral associate in 2009-2015 with Prof. K. Barry Sharpless's group at The Scripps Research. During his postdoctoral work at Scripps Research, Jiajia discovered the 'Sulfur(VI) Fluoride Exchange (SuFEx) reaction' with Professor Sharpless. He is currently a professor at Shanghai Jiao Tong University. His research interests mainly focus on 'SuFEx click chemistry.'
Topic: The FSO2N3, an Unexpected Journey
Abstract: In 2018, our team discovered a mild and efficient process to prepare FSO2N3, then revealed the efficient diazo transfer process of FSO2N3. This discovery changed the scientific goal of our team. We realized we could construct a large-scale azide building blocks library through this new process. Then, we coupled the ligand-accelerated CuAAC reaction of any given terminal alkynes and our azides to rapidly generate a triazole library in a liquid phase at low concentration. Without separation and purification, we could use these modular click chemistry libraries to search for molecule functions. Especially a phenotypic screen for biological functions, a feat that previous combinatorial libraries could not achieve. In the past five years, we have been trying to push the number of azides to 5,000, and now we are aiming for 10,000.
Reversible RNA methylation in gene expression regulation
Prof. Chuan He
Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered two RNA demethylases, FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that reversible RNA modification could impact biological regulation analogous to the well-known reversible DNA and histone chemical modifications. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target mRNA. Functional studies reveal m6A methylation as a critical mechanism to group transcripts for coordinated metabolism, translation, and decay, allowing timely and coordinated protein synthesis and transcriptome switching during cell differentiation and development. I will present our recent work elucidating transcriptional regulation through m6A methylation and demethylation, and impacts of this regulation on mammalian early development as well as plant growth.
Lnc-ing RNA processing and function
Prof. Ling-Ling Chen
New Cornerstone Science Laboratory, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS)
Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs. By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several RNA species with unexpected formats. These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by distinct mechanisms, including capping by small nucleolar RNA (snoRNA)–protein (snoRNP) complexes at their ends (sno-lncRNAs) or forming circular structures. We have shown that sno-lncRNAs and circular RNAs are involved in key gene regulation events and are implicated in Pradier-Will syndrome and autoimmune diseases. In this talk, I will discuss the mechanisms of their formation and function, as well as how we study one sno-lncRNA (SLERT) that has enabled us to uncover previously unknown organization and regulation in the human nucleolus.
Translating spatial cell atlas to tissue function
Prof. Xiao Wang
Department of Chemistry, Broad Institute, MIT
Spatially charting molecular cell types at single-cell resolution across the entire three-dimensional (3D) volume of the brain is critical to illustrating the molecular basis of the tissue anatomy and functions. Recent development of spatial transcriptomic methods has enabled scalable profiling of transcriptome-defined spatial cell atlas. Yet, there is still a big gap between spatial cell atlas and tissue function. In this presentation, I will introduce a few experimental and computational advances in our lab that further enable multi-modality deep profiling of cell types and states in situ, bridging single-cell molecular profiles with single-cell functional status in intact biological tissues and accelerating gene-to-function discoveries in development and diseases.
Keynote Speech: Wonder Chemistry on/in/of Water
TANG Ben Zhong
Session 2: Click Chemistry Tools For Studying Glycosylation
Moderator: WU Peng
Session 3: New Tools for The Investigation and Control of Protein Functions
Moderator: WU Peng
Session 4: New Tools for Imaging And Probing Nucleic Acids, Protein and Receptor Signaling
Moderator: SHUI Wenqing