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Thank you for signing up for the inaugural WLA Research Conference. Please read the following notice for a pleasant experience.
All participants need to register for the conference online at our official website and pay the registration fee and/or the banquet fee.
The registration fee is $200.00 per person and $50.00 per person for the banquet fee.
You can purchase up to 5 extra tickets with each having their contact information.
A full refund is available before July 20, 2020 (Beijing Time). After this date, refunds will not be provided.
You are welcome to bring your research poster and display at the Poster Session of WRC.
You are encouraged to read the Poster Presenter Guidelines to help you better prepare for the session.
The Best Poster Prize will be awarded at the closing of the meeting on July 28.
Please bring your ID document to pick up your badge and meeting materials at the Registration table on July 26, 2023, 10 am - 2 pm.
Please wear your badge during the meeting. Contact WLA Labs staff immediately if lost, and temporary one will be provided.
Meeting materials include a program book, a note pad, a pen and a WRC bag.
English is the working language of the meeting. No interpretation service is provided.
The venue of the meeting is La Salle Versailles, Shanghai Science Hall. You can take metro line 13, at Middle Huaihai Road, or drive here.
The parking lot is at right side of the building.
We recommend the following 2 premium hotels nearest to the meeting that can offer you a delightful experience:
a) Okura Garden Hotel Shanghai, five stars: No. 58, Maoming South Road
b) Intercontinental, five stars: No. 118, Ruijin 2nd Road
General inquiry, please contact info@wlalabs.com.cn.
In case of emergency, please contact 021-655 7670
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Last updated: May 18, 2023
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Last updated: May 18, 2023
You've already registered for this Conference. Please find more details in My Event .Thank you!
You've already registered for this Conference. Please find more details in My Event. Thank you!
Featuring talks by
Prof. WANG Chu
Professor, College of Chemistry and Molecular Engineering, Peking University
Topic: Chemical Proteomic Profiling of Functional Modifications by Reactive Metabolites
Prof. CHEN Peng
Professor, Chair, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University
Topic: Bioorthogonal Cleavage Chemistry for Protein Activation in Space and Time
Prof. Yimon AYE
Associate Professor, Swiss Federal Institute of Technology Lausanne
Topic: What We Do in the Dark: Illuminating Functional Responsivity, Signaling Activity, & Druggability of the Local Interactome in Living Systems
Prof. John ZHANG
COO, EVP, Cheerland Biotechnology Co., Ltd.
Topic: Next-Generation Intelligent Manufacturing Technology for Biological Products
Moderated by
Prof. WU Peng
Professor, the Department of Molecular Medicine, Scripps Research Institute
Topic: Tentative
New Tools for The Investigation and Control of Protein Functions
WANG Chu
Professor, College of Chemistry and Molecular Engineering, Peking University
Brief bio: Wang Chu, Professor, College of Chemistry and Molecular Engineering, Peking University. Dr. Wang received Ph.D. in 2007 from the University of Washington under the guidance of Prof. David Baker, training in the area of computational protein structural prediction and design. He then worked as a postdoctoral fellow with Prof. Benjamin Cravatt at Scripps Research Lo Jolla, and developed multiple chemical proteomic methods to profile reactive cysteines and modifications in proteomes. In 2014, he joined Peking University to start his independent career and was promoted to Tenured Professor of Chemical Biology in 2020. He has won the Young Chemical Biologist Award from the International Chemical Biology Society and the Distinguished Young Scholar Award from the National Natural Science Foundation of China. His research interest is to develop chemical and computational proteomics methods to enable quantitative profiling of functional enzymes, protein post-translational modifications as well as protein-ligand interactions in proteomes.
Topic: Chemical Proteomic Profiling of Functional Modifications by Reactive Metabolites
Abstract: Genome sequencing projects have revolutionized our view of the complexity of prokaryotic and eukaryotic proteomes, however, we are also left with a daunting challenge of functionally annotating these large number of predicted proteins. Chemical proteomic methods, such as activity-based protein profiling (ABPP), have been developed aiming at systematically discovering new functional targets directly from native proteomes. In this talk, I will present recent progresses from my laboratory which combines ABPP-based chemical proteomic, biochemical, and computational strategies to uncover functional sites of post-translational modifications by reactive metabolites in proteomes.
CHEN Peng
Professor, Chair Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University
Brief bio: Dr. CHEN Peng obtained a BS degree in Chemistry at Peking University in 2002, and a Ph.D. in Chemistry with Prof. HE Chuan at The University of Chicago in 2007. After a postdoctoral training at The Scripps Research Institute with Prof, Peter SCHULTZ, he started his independent career at Peking University in 2009. He is currently the Director of the Chemical Biology Division at the Chinese Chemical Society and the Executive Editor of ACS Chemical Biology. His research interest is at the interface of Chemistry and Biology.
His lab is a leading group in developing bioorthogonal cleavage reactions for chemically controlled protein activation and profiling in living systems. This has created a new direction in bioorthogonal chemistry for the gain-of-function study of proteins under living conditions. He employed this toolkit to study how the spatial-temporal organized human proteome is rewired during cancer and immune signaling, and his lab also exploited the potential of these new reactions in protein-based therapy.
Topic: Bioorthogonal Cleavage Chemistry for Protein Activation in Space and Time
Abstract: Employing small molecules or other chemical means to modulate the function of an intracellular protein of interest, particularly in a gain-of-function fashion, remains highly desired but challenging. In this talk, I will introduce a "genetically encoded chemical decaging" strategy that relies on our recently developed bioorthogonal cleavage reactions to control protein activation in living systems. These reactions exhibit high efficiency and low toxicity for decaging the chemically "masked" lysine or tyrosine residues on intracellular proteins, allowing the gain-of-function study of individual enzymes within living cells and mice. Most recently, with the assistance of computer-based design and screening, we further expanded our method from "precise decaging" of enzyme active-sites to "proximal decaging" of enzyme pockets. This new method, termed Computationally Aided and Genetically Encoded Proximal Decaging" (CAGE-prox) (CAGE-prox), showed general applicability for switching on the activity of a broad range of proteins under living conditions. I will end by showcasing exciting applications of our CAGE-prox technique on: i) constructing orthogonal and mutually exclusive kinase signaling cascades; ii) temporal caspase activation for time-resolved profiling of proteolytic events upon apoptosis; and iii) on-demand activation of bacterial effectors as potential protein prodrugs for cancer therapy. Finally, by coupling with the proximity-labeling enzymes that have been used for subcellular targeting, we further developed a spatial-temporal resolved proteomics strategy for subcellular proteome profiling in living cells.
Yimon AYE
Associate Professor, Swiss Federal Institute of Technology Lausanne
Brief bio: Aye received her combined B.S. & M.S. degree in Chemistry at the University of Oxford, UK, in 2004, and Ph.D. degree in Organic Chemistry with Prof. David Evans from Harvard University, in 2009. She then switched her research discipline to life science and trained with Prof. JoAnne Stubbe at MIT. Science in the Aye lab (https://leago.epfl.ch) – established in mid-2012 –seeks to understand non-canonical cell signaling processes. Her laboratory is most well-known for investigations into electrophile signaling, a nuanced communication mode whereby on-target engagement between reactive metabolites and target proteins, orchestrates precision responses at cellular/organismal levels. Contributions from here laboratory have been recognized by several international honors, with the most recent being the 2021 ACS Cope Scholars, International Chemical Biology Society Global Lectureship, 2022 Tetrahedron Young Investigator, and European Research Council grant awards.
Topic: What We Do in the Dark: Illuminating Functional Responsivity, Signaling Activity, & Druggability of the Local Interactome in Living Systems
Abstract : Prof. Yimon Aye will highlight how an organic chemistry-driven idea has evolved into an enabling chemical biology toolset that can address some of the long-standing as well as emerging key biomedical problems of importance in both fundamental research and translational science. Focus will be placed on our latest understanding of precision electrophile signaling mechanisms and how such precision localized electrophile delivery concept and associated tools open up new opportunities to simultaneously map and functionally validate our localized protein players and pathways in a chemical-function-guided manner, in the context of functional drug discovery and mode-of-action deconvolution.
John ZHANG
COO, EVP, Cheerland Biotechnology Co., Ltd.
Brief bio: Dr. John Zhang earned his Ph.D. degree in the United States from EVMS and continued on two consecutive postdoctoral trainings for an additional five years at The Johns Hopkins University School of Medicine in Molecular Biology and OSU in Molecular Virology, respectively. Currently, he is a Chief Operation Officer and Executive Vice President at Cheerland Precision Medicine Group. Dr. Zhang returned to work in China in 2016 and served as a vice president of manufacturing operation and process development at Qilu Pharmaceutical followed by working as VP at BeiGene and Zai Lab Incorporations in charge of Manufacturing & Process technology development. Before returning to China, he worked for Lonza Biologics in the US engaging in PC/PV studies & supporting 20k-L bioreactor manufacturing operation, and for Bio-Techne group in charge of manufacturing operation. Dr. Zhang has more than 25 years of experience in both basic research at the University of Illinois at Chicago as an Assistant Professor for 7 years and biologics drug development in pharmaceuticals in the last 14 years. He has also published more than 25 peer-reviewed papers in journals and developed a few commercialized biologics products in the US.
Topic: Next-Generation Intelligent Manufacturing Technology for Biological Products
Abstract :
Cheerland's CLB world-class international team achieved many technological improvements and innovations along service lines and established industry-leading, next-generation development and production platforms. All the innovations bring real benefits to our clients and patients, providing the world with high-quality, low-cost, safe, and effective biomedicine.
— Improved design of extra-large stainless steel bioreactors
— Innovative DS facility & production process design
— Improved down-stream purification system configuration
— Integrated Digital Quality Systems
CLB strives to implement comprehensive GMP management on drugs, and continuously improve and enhance the Quality Management System, which provides the foundation for manufacturing systems that are linked and function within it, thus providing an adequate level of integration of the systems. We adopt a dynamic management concept to establish, revise, and implement various systems and standards of the enterprise, in order to continuously meet the requirements of customers through advanced management concepts and tools such as deviation management, change management, and quality risk management.
Reversible RNA methylation in gene expression regulation
Prof. Chuan He
Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered two RNA demethylases, FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that reversible RNA modification could impact biological regulation analogous to the well-known reversible DNA and histone chemical modifications. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target mRNA. Functional studies reveal m6A methylation as a critical mechanism to group transcripts for coordinated metabolism, translation, and decay, allowing timely and coordinated protein synthesis and transcriptome switching during cell differentiation and development. I will present our recent work elucidating transcriptional regulation through m6A methylation and demethylation, and impacts of this regulation on mammalian early development as well as plant growth.
Lnc-ing RNA processing and function
Prof. Ling-Ling Chen
New Cornerstone Science Laboratory, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS)
Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs. By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several RNA species with unexpected formats. These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by distinct mechanisms, including capping by small nucleolar RNA (snoRNA)–protein (snoRNP) complexes at their ends (sno-lncRNAs) or forming circular structures. We have shown that sno-lncRNAs and circular RNAs are involved in key gene regulation events and are implicated in Pradier-Will syndrome and autoimmune diseases. In this talk, I will discuss the mechanisms of their formation and function, as well as how we study one sno-lncRNA (SLERT) that has enabled us to uncover previously unknown organization and regulation in the human nucleolus.
Translating spatial cell atlas to tissue function
Prof. Xiao Wang
Department of Chemistry, Broad Institute, MIT
Spatially charting molecular cell types at single-cell resolution across the entire three-dimensional (3D) volume of the brain is critical to illustrating the molecular basis of the tissue anatomy and functions. Recent development of spatial transcriptomic methods has enabled scalable profiling of transcriptome-defined spatial cell atlas. Yet, there is still a big gap between spatial cell atlas and tissue function. In this presentation, I will introduce a few experimental and computational advances in our lab that further enable multi-modality deep profiling of cell types and states in situ, bridging single-cell molecular profiles with single-cell functional status in intact biological tissues and accelerating gene-to-function discoveries in development and diseases.
Special Remarks
Moderator: Michael LEVITT
Keynote Speech: Wonder Chemistry on/in/of Water
TANG Ben Zhong
Session 1: New Chemistry And Tools
Moderator: DONG Jiajia
Session 2: Click Chemistry Tools For Studying Glycosylation
Moderator: WU Peng
Session 4: New Tools for Imaging And Probing Nucleic Acids, Protein and Receptor Signaling
Moderator: SHUI Wenqing