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Thank you for signing up for the inaugural WLA Research Conference. Please read the following notice for a pleasant experience.
All participants need to register for the conference online at our official website and pay the registration fee and/or the banquet fee.
The registration fee is $200.00 per person and $50.00 per person for the banquet fee.
You can purchase up to 5 extra tickets with each having their contact information.
A full refund is available before July 20, 2020 (Beijing Time). After this date, refunds will not be provided.
You are welcome to bring your research poster and display at the Poster Session of WRC.
You are encouraged to read the Poster Presenter Guidelines to help you better prepare for the session.
The Best Poster Prize will be awarded at the closing of the meeting on July 28.
Please bring your ID document to pick up your badge and meeting materials at the Registration table on July 26, 2023, 10 am - 2 pm.
Please wear your badge during the meeting. Contact WLA Labs staff immediately if lost, and temporary one will be provided.
Meeting materials include a program book, a note pad, a pen and a WRC bag.
English is the working language of the meeting. No interpretation service is provided.
The venue of the meeting is La Salle Versailles, Shanghai Science Hall. You can take metro line 13, at Middle Huaihai Road, or drive here.
The parking lot is at right side of the building.
We recommend the following 2 premium hotels nearest to the meeting that can offer you a delightful experience:
a) Okura Garden Hotel Shanghai, five stars: No. 58, Maoming South Road
b) Intercontinental, five stars: No. 118, Ruijin 2nd Road
General inquiry, please contact info@wlalabs.com.cn.
In case of emergency, please contact 021-655 7670
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Last updated: May 18, 2023
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Last updated: May 18, 2023
You've already registered for this Conference. Please find more details in My Event .Thank you!
You've already registered for this Conference. Please find more details in My Event. Thank you!
Featuring talks by
Prof. Yanhui Xu
Fudan University Shanghai Cancer Center, China
Topic: Structural insights into preinitiation complex assembly on chromatin
Prof. Alexey Amunts
Stockholm University, Sweden
Topic: How genes become machines in mitochondria
Chaired by
Prof. Yigong Shi
Westlake University, China
Topic: Mechanism of RNA splicing by the spliceosome
This session will delve into the intricate molecular mechanisms that underlie the Central Dogma of molecular biology. Session talks will shed light on the critical role of RNA splicing in generating protein diversity and regulating gene expression, how 3D structure of a human cell’s genome being transcribed, the dynamic interactions between DNA, regulatory factors, and transcriptional machinery, and how molecular processes contribute to mitochondrial function and cellular metabolism. Attendees will have the opportunity to explore cutting-edge research findings and atomic-level details of RNA splicing, understand the structural intricacies of preinitiation complex assembly on chromatin, and explore the fascinating world of gene expression within mitochondria. It promises to be an engaging and enlightening session that will deepen our understanding of these fundamental molecular processes and their significance in biology and medicine.
Yigong Shi, Ph.D., mainly uses biochemical and biophysical methods to study the molecular mechanism of cell apoptosis, the structure, and function of important membrane proteins, and intracellular biological macromolecules. He analyzes the key complex structure of eukaryotic messenger RNA splicing bodies revealing molecule layer mechanisms. Shi is a recipient of the Searle Scholar Award, the Rita Allen Scholar Award, the Irving Sigal Young Investigator Award (2003), the Raymond and Beverly Sackler International Prize in Biophysics (2010), the Qiu Shi Outstanding Scientist Award of the Qiushi Foundation (2010), the CC Tan Life Science Achievement Award (2010), the Gregori Aminoff Prize of the Royal Swedish Academy of Sciences (2014), the Wu Jieping-Paul Janssen Medicine and Pharmaceutical Science Award (2014), the "You Bring Charm to the World Award" (2015-2016), the Science and Technology Achievement Prize of the Ho-Leung-Ho-Lee Foundation (2016), the Future Science Prize of the Life Sciences Prize (2017), the achievement award of the VCANBIO Award for Biosciences and Medicine (2017), and Tan Kah Kee Science Awards(2020). He was also nominated as a Foreign Associate of the European Molecular Biology Organization in 2013.
Xiaoliang Sunney Xie, Ph.D., is the Director of Changping Laboratory, the Lee Shau-kee Professor and Dean of Faculty of Sciences at Peking University. He received his B.Sc. in Chemistry from Peking University in 1984, and Ph.D. in Physical Chemistry from University of California at San Diego in 1990. He became the first tenured professor in 1998 and the first endowed Professor in 2009 at Harvard University among Chinese scholars since China's reform and opening up. He relocated to Peking University in 2018.
Xie has been a pioneer of single-molecule biophysical chemistry, coherent Raman scattering microscopy and single-cell genomics. The single-cell whole genome amplification methods that his group invented has to date benefited over 4,000 families with monogenic diseases by successfully preventing the passing of disease-causing mutations to their offspring. In fighting against the COVID-19 pandemic, Xie's team has identified a broad-spectrum neutralizing antibody against all SARS-CoV-2 variants, which has been licensed to Sinovac and is undergoing clinical trials.
Xie received numerous international awards, most notably Albany Prize in Medicine and Biomedical Research, Peter Debye Award in Physical Chemistry of American Chemical Society and Founders Award of Biophysical Society.
Yanhui Xu, Ph.D., received his Ph.D. from Tsinghua University in Zihe Rao lab, where he studied the mechanism of virus fusion. He went to Princeton University as a postdoctoral scholar in Yigong Shi lab, where he studied the structural basis for assembly of protein phosphatase 2A holoenzyme. He moved to Fudan University in 2008 as a principal investigator. His lab was investigating the structure and function of transcription regulation by using biochemistry and cryo-electron microscopy.
Alexey Amunts, Ph.D., is an Associate Professor at Science for Life Laboratory, Stockholm. He studied structural biology at the Tel Aviv University and specialized in bioenergetics. Following his postdoctoral studies at the MRC Laboratory of Molecular Biology with Venki Ramakrishnan on cryo-EM studies of a mitoribosome that became known as the "Resolution Revolution," he established an independent group in Stockholm. The group is funded by the ERC and studies mitochondrial protein synthesis and energy production at the molecular and cellular level, and examines how these fundamental processes are affected by natural selection and diseases. Alexey Amunts is EMBO Young Investigator, and the recipient of the Cancer Foundation Junior Investigator Award.
Reversible RNA methylation in gene expression regulation
Prof. Chuan He
Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered two RNA demethylases, FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that reversible RNA modification could impact biological regulation analogous to the well-known reversible DNA and histone chemical modifications. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target mRNA. Functional studies reveal m6 A methylation as a critical mechanism to group transcripts for coordinated metabolism, translation, and decay, allowing timely and coordinated protein synthesis and transcriptome switching during cell differentiation and development. I will present our recent work elucidating transcriptional regulation through m6A methylation and demethylation, and impacts of this regulation on mammalian early development as well as plant growth.
Lnc-ing RNA processing and function
Prof. Ling-Ling Chen
New Cornerstone Science Laboratory, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS)
Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs. By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several RNA species with unexpected formats. These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by distinct mechanisms, including capping by small nucleolar RNA (snoRNA)–protein (snoRNP) complexes at their ends (sno-lncRNAs) or forming circular structures. We have shown that sno-lncRNAs and circular RNAs are involved in key gene regulation events and are implicated in Pradier-Will syndrome and autoimmune diseases. In this talk, I will discuss the mechanisms of their formation and function, as well as how we study one sno-lncRNA (SLERT) that has enabled us to uncover previously unknown organization and regulation in the human nucleolus.
Translating spatial cell atlas to tissue function
Prof. Xiao Wang
Department of Chemistry, Broad Institute, MIT
Spatially charting molecular cell types at single-cell resolution across the entire three-dimensional (3D) volume of the brain is critical to illustrating the molecular basis of the tissue anatomy and functions. Recent development of spatial transcriptomic methods has enabled scalable profiling of transcriptome-defined spatial cell atlas. Yet, there is still a big gap between spatial cell atlas and tissue function. In this presentation, I will introduce a few experimental and computational advances in our lab that further enable multi-modality deep profiling of cell types and states in situ, bridging single-cell molecular profiles with single-cell functional status in intact biological tissues and accelerating gene-to-function discoveries in development and diseases.