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Thank you for signing up for the inaugural WLA Research Conference. Please read the following notice for a pleasant experience.
All participants need to register for the conference online at our official website and pay the registration fee and/or the banquet fee.
The registration fee is $200.00 per person and $50.00 per person for the banquet fee.
You can purchase up to 5 extra tickets with each having their contact information.
A full refund is available before July 20, 2020 (Beijing Time). After this date, refunds will not be provided.
You are welcome to bring your research poster and display at the Poster Session of WRC.
You are encouraged to read the Poster Presenter Guidelines to help you better prepare for the session.
The Best Poster Prize will be awarded at the closing of the meeting on July 28.
Please bring your ID document to pick up your badge and meeting materials at the Registration table on July 26, 2023, 10 am - 2 pm.
Please wear your badge during the meeting. Contact WLA Labs staff immediately if lost, and temporary one will be provided.
Meeting materials include a program book, a note pad, a pen and a WRC bag.
English is the working language of the meeting. No interpretation service is provided.
The venue of the meeting is La Salle Versailles, Shanghai Science Hall. You can take metro line 13, at Middle Huaihai Road, or drive here.
The parking lot is at right side of the building.
We recommend the following 2 premium hotels nearest to the meeting that can offer you a delightful experience:
a) Okura Garden Hotel Shanghai, five stars: No. 58, Maoming South Road
b) Intercontinental, five stars: No. 118, Ruijin 2nd Road
General inquiry, please contact info@wlalabs.com.cn.
In case of emergency, please contact 021-655 7670
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Last updated: May 18, 2023
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Last updated: May 18, 2023
You've already registered for this Conference. Please find more details in My Event .Thank you!
You've already registered for this Conference. Please find more details in My Event. Thank you!
Featuring talks by
Prof. Georgios Skiniotis
Stanford University, U.S.A.
Topic: Time-resolved cryoEM of G protein activation by a GPCR
Prof. Aashish Manglik
UC San Francisco, U.S.A.
Topic: Seeing scents: Towards a structural basis of olfaction
Chaired by
Prof. Carol Robinson
University of Oxford, UK
Topic: From recombinant complexes in detergent micelles to receptor signaling across native membranes – The promises and pitfalls of native mass spectrometry
This session aims to delve into the fascinating world of membrane proteins and their crucial role in cellular communication. This session features three distinguished speakers, who will explore into different aspects of cellular signaling and molecular recognition. One lecture focuses on the dynamic process of G protein activation by G protein-coupled receptors (GPCRs), showcasing the application of time-resolved cryoEM techniques. One lecture aims to uncover the structural basis of olfaction, exploring the challenges in understanding odorant recognition. Another lecture examines the promises and challenges of using native mass spectrometry in studying receptor signaling across cell membranes, highlighting its potential in deciphering complex interactions. Overall, this session will offer dynamic insights into receptor signaling, keeping attendees informed of the latest advancements.
Carol Robinson, Ph.D., is Dr. Lee's Professor of Chemistry at the University of Oxford and is the first Director of Oxford's Kavli Institute for Nanoscience Discovery. She is recognized for establishing mass spectrometry as a viable technology to study the structure and function of proteins. Robinson graduated from the Royal Society of Chemistry in 1979 and completed her Ph.D. at Cambridge University. After a career break of eight years to focus on her family, she became a Professor of Mass Spectrometry at Cambridge, returning to Oxford in 2009 to take up her current position. Her work has attracted numerous awards, including the 2022 Benjamin Franklin Medal in Chemistry, the 2022 Louis Jeantet Prize for Medicine, and most recently, the ASMS John B. Fenn Award for Distinguished Contribution in Mass Spectrometry. Robinson is the former President of the Royal Society of Chemistry, a Foreign Associate of the National Academy of Sciences U.S.A., and an International Honorary Member of the American Academy of Arts and Sciences. She was awarded a DBE in 2013 for services to science and industry.
Georgios Skiniotis, Ph.D., is Professor of Molecular & Cellular Physiology and of Structural Biology at Stanford University. He is also the Scientific Director of the Stanford CryoEM Center (cEMc) at Stanford University. Skiniotis is a structural biologist with expertise in electron cryomicroscopy (cryoEM). Skiniotis has exploited the power of cryoEM to study a wide range of important biological "machines" or macromolecular assemblies. His main interests are on the mechanisms of transmembrane signal instigation with a particular focus on G protein-coupled receptors and cytokine receptors. The application of cryoEM to such systems has also driven him to explore and refine approaches for resolving technically challenging problems.
The Skiniotis laboratory seeks to resolve structural and mechanistic questions underlying biological processes that are central to cellular physiology. Their investigations employ primarily cryo-electron microscopy (cryoEM) and 3D reconstruction techniques complemented by biochemistry, biophysics and simulation methods to obtain a dynamic view into the macromolecular complexes carrying out these processes. The main theme in the lab is the structural biology of cell surface receptors that mediate intracellular signaling and communication. The current main focus is the exploration of the mechanisms responsible for transmembrane signal instigation in cytokine receptors and G protein coupled receptor (GPCR) complexes.
Aashish Manglik, M.D., Ph.D., is an Associate Professor in the Departments of Pharmaceutical Chemistry and Anesthesia at UC San Francisco. Manglik received his B.A. in Biology and Chemistry from Washington University in St. Louis and his M.D./Ph.D. from Stanford University. His lab seeks to understand how cells sense and respond to their external environment, with a focus on transmembrane signaling coordinated by G protein-coupled receptors. Manglik was named a Pew, Searle, Klingenstein, and Vallee Scholar and is a recipient of the NIH Director's Early Independence Award and the Amgen Young Investigator Award.
Reversible RNA methylation in gene expression regulation
Prof. Chuan He
Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered two RNA demethylases, FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that reversible RNA modification could impact biological regulation analogous to the well-known reversible DNA and histone chemical modifications. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target mRNA. Functional studies reveal m6A methylation as a critical mechanism to group transcripts for coordinated metabolism, translation, and decay, allowing timely and coordinated protein synthesis and transcriptome switching during cell differentiation and development. I will present our recent work elucidating transcriptional regulation through m6A methylation and demethylation, and impacts of this regulation on mammalian early development as well as plant growth.
Lnc-ing RNA processing and function
Prof. Ling-Ling Chen
New Cornerstone Science Laboratory, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS)
Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs. By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several RNA species with unexpected formats. These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by distinct mechanisms, including capping by small nucleolar RNA (snoRNA)–protein (snoRNP) complexes at their ends (sno-lncRNAs) or forming circular structures. We have shown that sno-lncRNAs and circular RNAs are involved in key gene regulation events and are implicated in Pradier-Will syndrome and autoimmune diseases. In this talk, I will discuss the mechanisms of their formation and function, as well as how we study one sno-lncRNA (SLERT) that has enabled us to uncover previously unknown organization and regulation in the human nucleolus.
Translating spatial cell atlas to tissue function
Prof. Xiao Wang
Department of Chemistry, Broad Institute, MIT
Spatially charting molecular cell types at single-cell resolution across the entire three-dimensional (3D) volume of the brain is critical to illustrating the molecular basis of the tissue anatomy and functions. Recent development of spatial transcriptomic methods has enabled scalable profiling of transcriptome-defined spatial cell atlas. Yet, there is still a big gap between spatial cell atlas and tissue function. In this presentation, I will introduce a few experimental and computational advances in our lab that further enable multi-modality deep profiling of cell types and states in situ, bridging single-cell molecular profiles with single-cell functional status in intact biological tissues and accelerating gene-to-function discoveries in development and diseases.