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Thank you for signing up for the inaugural WLA Research Conference. Please read the following notice for a pleasant experience.
All participants need to register for the conference online at our official website and pay the registration fee and/or the banquet fee.
The registration fee is $200.00 per person and $50.00 per person for the banquet fee.
You can purchase up to 5 extra tickets with each having their contact information.
A full refund is available before July 20, 2020 (Beijing Time). After this date, refunds will not be provided.
You are welcome to bring your research poster and display at the Poster Session of WRC.
You are encouraged to read the Poster Presenter Guidelines to help you better prepare for the session.
The Best Poster Prize will be awarded at the closing of the meeting on July 28.
Please bring your ID document to pick up your badge and meeting materials at the Registration table on July 26, 2023, 10 am - 2 pm.
Please wear your badge during the meeting. Contact WLA Labs staff immediately if lost, and temporary one will be provided.
Meeting materials include a program book, a note pad, a pen and a WRC bag.
English is the working language of the meeting. No interpretation service is provided.
The venue of the meeting is La Salle Versailles, Shanghai Science Hall. You can take metro line 13, at Middle Huaihai Road, or drive here.
The parking lot is at right side of the building.
We recommend the following 2 premium hotels nearest to the meeting that can offer you a delightful experience:
a) Okura Garden Hotel Shanghai, five stars: No. 58, Maoming South Road
b) Intercontinental, five stars: No. 118, Ruijin 2nd Road
General inquiry, please contact info@wlalabs.com.cn.
In case of emergency, please contact 021-655 7670
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Last updated: May 18, 2023
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Last updated: May 18, 2023
You've already registered for this Conference. Please find more details in My Event .Thank you!
You've already registered for this Conference. Please find more details in My Event. Thank you!
Featuring talks by
Prof. Nenad Ban
ETH Zürich, Switzerland
Topic: Revealing the remarkable machinery for production of proteins in human cells
Prof. Roger Kornberg
Stanford University, U.S.A.
Topic: Chromatin, chromosomes, and transcription
Chaired by
Prof. Wolfgang Baumeister
Max Planck Institute of Biochemistry, Germany
Topic: Structural biology in situ: The promise and challenges of cryo-electron tomography
This session will discuss the latest trends and developments in the field of structural biology. It will provide insights into the dynamic structures and complex molecular machines required for the proper functioning of human cells. Topics will include the complex and elegant mechanisms involved in protein synthesis, the structural biology of DNA packaging, and the advances in structural biology techniques used to visualize the molecular machines that operate within cells. These topics are all of significant importance in understanding human health and disease and represent some of the latest advances in biological research. The session will provide attendees with a broader understanding of the latest developments and innovations in structural biology. Overall, it promises to be a lively and informative discussion of some of the most exciting topics in structural biology today.
Wolfgang Baumeister, Ph.D., obtained his Ph.D. from the University of Düsseldorf in 1973. In 1981/82, he spent time at the Cavendish Laboratory in Cambridge, England, as a Heisenberg Fellow. In 1982 he joined the Max Planck Institute of Biochemistry in Martinsried as a group leader. Since 1988 he has been a Scientific Member of the Max Planck Society and Director of the Department of Structural Biology. He is an Honorary Professor at the Technical University of Munich in the Departments of Physics and Chemistry. Since 2018 he is also a Distinguished Adjunct Professor at ShanghaiTech University. He is a member of the German Academy of Sciences, Leopoldina, the US National Academy of Sciences, and the American Academy of Arts and Sciences and the recipient of numerous awards, including the Otto-Warburg Medal, the Louis-Jeantet Prize for Medicine, the Stein and Moore Award, the Harvey Prize, the Ernst Jung Medal for Medicine and the Alexander Hollaender Award in Biophysics.
Baumeister's main interest is the development of new tools and methods for the structural characterization of molecules and cells. He had a pioneering role in the development of cryo-electron tomography for structural studies of molecular and supramolecular structures in situ, i.e., in their native cellular habitats. A major focus of his work is the molecular machinery of protein degradation, in particular via the ubiquitin-proteasome pathway, and autophagy.
Roger Kornberg, Ph.D., is the Winzer Professor in Medicine in the Department of Structural Biology at Stanford University. In his doctoral research, he demonstrated the diffusional motions of lipids in membranes, termed flip-flop and lateral diffusion. He was a postdoctoral fellow and member of the scientific staff at the Laboratory of Molecular biology in Cambridge, England from 1972-5, where he discovered the nucleosome, the basic unit of DNA coiling in chromosomes. He moved to his present position in 1978, where his research has focused on the mechanism and regulation of eukaryotic gene transcription. Notable findings include the demonstration of the role of nucleosomes in transcriptional regulation, the establishment of a yeast RNA polymerase II transcription system and the isolation of all the proteins involved, the discovery of the Mediator of transcriptional regulation, the development of two-dimensional protein crystallization and its application to transcription proteins, and the atomic structure determination of an RNA polymerase II transcribing complex. Kornberg was elected to the National Academy of Sciences in 1993. He has received many awards, including the Welch Prize (2001), highest award in chemistry in the United States, the Leopold Mayer Prize (2002), highest award in biomedical sciences of the French Academy of Sciences, and the Nobel Prize in Chemistry (unshared, 2006).
Nenad Ban, Ph.D., is a Professor of Structural Molecular Biology at ETH Zürich since 2000. He is a pioneer in studying gene expression mechanisms and the participating protein synthesis machinery in all kingdoms of life, both in terms of the chemistry of the process and with respect to molecular mechanisms of translation regulation, and of co-translational folding, processing and targeting to membranes. His group revealed the mechanisms behind the key steps in eukaryotic cytoplasmic and mitochondrial translation with a broad impact on a wide range of fields in biology, chemistry and biomedicine.
Ban is a member of the National Academy of Sciences of the United States of America, the European Molecular Biology Organization, and the German Academy of Sciences. He is the recipient of several prizes and awards including the Heinrich Wieland Prize, the Roessler Prize of the ETH Zürich, the Latsis Prize, the Friedrich Miescher Prize of the Swiss Society for Biochemistry, the Spiridon Brusina Medal, and the AAAS Newcomb Cleveland Prize.
Reversible RNA methylation in gene expression regulation
Prof. Chuan He
Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered two RNA demethylases, FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that reversible RNA modification could impact biological regulation analogous to the well-known reversible DNA and histone chemical modifications. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target mRNA. Functional studies reveal m6A methylation as a critical mechanism to group transcripts for coordinated metabolism, translation, and decay, allowing timely and coordinated protein synthesis and transcriptome switching during cell differentiation and development. I will present our recent work elucidating transcriptional regulation through m6A methylation and demethylation, and impacts of this regulation on mammalian early development as well as plant growth.
Lnc-ing RNA processing and function
Prof. Ling-Ling Chen
New Cornerstone Science Laboratory, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS)
Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs. By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several RNA species with unexpected formats. These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by distinct mechanisms, including capping by small nucleolar RNA (snoRNA)–protein (snoRNP) complexes at their ends (sno-lncRNAs) or forming circular structures. We have shown that sno-lncRNAs and circular RNAs are involved in key gene regulation events and are implicated in Pradier-Will syndrome and autoimmune diseases. In this talk, I will discuss the mechanisms of their formation and function, as well as how we study one sno-lncRNA (SLERT) that has enabled us to uncover previously unknown organization and regulation in the human nucleolus.
Translating spatial cell atlas to tissue function
Prof. Xiao Wang
Department of Chemistry, Broad Institute, MIT
Spatially charting molecular cell types at single-cell resolution across the entire three-dimensional (3D) volume of the brain is critical to illustrating the molecular basis of the tissue anatomy and functions. Recent development of spatial transcriptomic methods has enabled scalable profiling of transcriptome-defined spatial cell atlas. Yet, there is still a big gap between spatial cell atlas and tissue function. In this presentation, I will introduce a few experimental and computational advances in our lab that further enable multi-modality deep profiling of cell types and states in situ, bridging single-cell molecular profiles with single-cell functional status in intact biological tissues and accelerating gene-to-function discoveries in development and diseases.